6533b7d2fe1ef96bd125e295

RESEARCH PRODUCT

Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?

Elena H Martínez-lapiscinaJaime AlgortaXavier Pintó SalaJoaquin Fernández-crehuet NavajasBernardo CostaJosep BasoraRosa CasasJuan José Cabré VilaEstefania ToledoItziar ZazpePaula CarrascoMario Gutiérrez-bedmarMontserrat FitóFrancisco M Martín LujánEmili CorbellaJosé V SorlíJosé Manuel Santos LozanoPilar Buil-cosialesLuis Serra-majemJordi Salas-salvadóMiguel-angel MuñozNancy Babio SánchezDora RomagueraRafel M. PrietoErnest VinyolesJ Alfredo Martínez HernándezAlmudena Sanchez VillegasJaume MarrugatJoan D. Fernandez-ballart

subject

MaleTime FactorsMediterranean dietEndocrinology Diabetes and MetabolismSistema cardiovascular -- MalaltiesMedicine (miscellaneous)Diet MediterraneanBody Mass IndexRisk FactorsMyocardial infarctionStrokeAbdominal obesityAdiposityAged 80 and overNutrition and DieteticsIncidenceMiddle AgedCardiovascular diseasePrimary PreventionTreatment OutcomeCardiovascular diseasesQuartileCardiovascular DiseasesObesity AbdominalFemaleDietamedicine.symptomWaist CircumferenceCardiology and Cardiovascular Medicinemedicine.medical_specialtyWaistWaist-to-height ratioMediterranean cookingMediterranean dietInternal medicineCuina mediterràniamedicineHumansDieta -- Mediterrània Regió de laAgedProportional Hazards Modelsbusiness.industryMalalties cardiovascularsProtective Factorsmedicine.diseaseConfidence intervalDietDietary interventionEndocrinologySpainMultivariate AnalysisbusinessBody mass index

description

BACKGROUND AND AIM: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. METHODS AND RESULTS: We assessed the relationship between baseline waist-to-height ratio (WHtR) and major cardiovascular events during a median follow-up of 4.8 years in the Prevention with Mediterranean Diet (PREDIMED) randomized primary prevention trial, which tested a MeDiet against a control diet (advice on a low-fat diet). We also examined whether the MeDiet intervention was able to counteract the detrimental cardiovascular effects of an increased WHtR. The trial included 7447 participants (55-80 years old, 57% women) at high cardiovascular risk but free of cardiovascular disease (CVD) at enrollment. An increased risk of CVD events (myocardial infarction, stroke, or cardiovascular death) was apparent for the highest versus the lowest quartile of WHtR (multivariable-adjusted hazard ratio: 1.98) (95% confidence interval: 1.10-3.57; linear trend: p = 0.019) only in the control-diet group, but not in the two groups allocated to intervention with MeDiet (p for interaction = 0.034). This apparent interaction suggesting that the intervention counterbalanced the detrimental cardiovascular effects of adiposity was also significant for body mass index (BMI) (p = 0.01) and waist circumference (p = 0.043). CONCLUSIONS: The MeDiet may counteract the harmful effects of increased adiposity on the risk of CVD. Supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through specific grants (RTIC G03/140; RTIC-RD 06/0045, to Prof. Martínez-González and CIBERobn), and by Fondo de Investigación Sanitaria eISCIII (PI04-2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and/nP11/02505), Ministerio Ciencia e Innovación (AGL-2009-13906-C02 and AGL2010-22319-C03), Fundación Mapfre 2010, Consejería Salud Junta de Andalucía (PI0105/2007), Health Department of Catalonia, Generalitat Valenciana (ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, CS2010-AP-111, and CS2011-AP-042), and Regional Government of Navarra (P27/2011). ET is supported by a Rio Hortega post-residency fellow of the ISCIII

yearjournalcountryeditionlanguage
2015-03-11
10.1016/j.numecd.2015.03.001http://hdl.handle.net/2445/178115