6533b7d2fe1ef96bd125ea0c

RESEARCH PRODUCT

Stoichiometric and kinetic study of the 99Tc-DMSA complex obtained with stannous excess: A possible model for the physico-chemical behaviour of the radiopharmaceutical 99mTc-DMSA

Jorge GalvezJ.l. MorenoR. Garcia

subject

RadiationNuclear Energy and EngineeringOxidation stateChemistry99mTc-DMSAInorganic chemistryAnalytical chemistrySN2 reactionRadiology Nuclear Medicine and imagingKinetic energyStoichiometry

description

A stoichiometric and kinetic study was made of the 99mTc-DMSA complex obtained in the presence of large amounts of Sn2+. It is demonstrated that the Tc oxidation state is 3+. It is established that the complex degrades to another one if there is an Sn2+ deficiency. These results were confirmed by spectroscopic and spectrophotometric methods.

https://doi.org/10.1016/0020-708x(82)90006-0