Search results for "99mTc-DMSA"
showing 3 items of 3 documents
Physico-chemical study of the radiopharmaceuticals 99mTc-DMSA, 99mTc-EDTA and 99mTc-DTPA interaction with plasmatic proteins.
1989
This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA less than 99mTc-DMSA(C1) less than 99mTc-EDTA less than 99mTc-DMSA(C2) where C1 and C2 represent two different Tc-DMSA complexes. The thermodynamic study suggests a quantitative relationship of radiopharmaceutical:protein = 1:1 and an almost nonexistent influence of the temperature, which means that the interacting forces in this process are relatively weak.
Stoichiometric and kinetic study of the 99Tc-DMSA complex obtained with stannous excess: A possible model for the physico-chemical behaviour of the r…
1982
A stoichiometric and kinetic study was made of the 99mTc-DMSA complex obtained in the presence of large amounts of Sn2+. It is demonstrated that the Tc oxidation state is 3+. It is established that the complex degrades to another one if there is an Sn2+ deficiency. These results were confirmed by spectroscopic and spectrophotometric methods.
Stability of the radiopharmaceutical []DMSA: Study of the ligand exchange reaction with [99Tc]EDTA
1983
Abstract A kinetic study was made of the ligand exchange reaction between [ 99 m Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[ 99 m Tc]EDTA and [ 99 m Tc]DMSA—have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.