6533b7d9fe1ef96bd126c200

RESEARCH PRODUCT

Physico-chemical study of the radiopharmaceuticals 99mTc-DMSA, 99mTc-EDTA and 99mTc-DTPA interaction with plasmatic proteins.

J. Galvez AlvarezA.farga MartiR. Garcia DomenechO.abril Mendez

subject

99mtc dtpaPentetic acid99mTc-DMSAGeneral Engineeringchemistry.chemical_elementTechnetiumPlasma protein bindingBlood ProteinsOrganotechnetium CompoundsPentetic AcidTechnetiumBlood proteinschemistry.chemical_compoundchemistryBiochemistryTechnetium Tc 99m Dimercaptosuccinic AcidTechnetium Tc 99m PentetateEdetic AcidTechnetium Tc 99m Dimercaptosuccinic AcidSulfhydryl CompoundsSuccimerEdetic AcidProtein Binding

description

This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA less than 99mTc-DMSA(C1) less than 99mTc-EDTA less than 99mTc-DMSA(C2) where C1 and C2 represent two different Tc-DMSA complexes. The thermodynamic study suggests a quantitative relationship of radiopharmaceutical:protein = 1:1 and an almost nonexistent influence of the temperature, which means that the interacting forces in this process are relatively weak.

yearjournalcountryeditionlanguage
1989-01-01International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
10.1016/0883-2889(89)90141-xhttps://pubmed.ncbi.nlm.nih.gov/2551850