6533b7d2fe1ef96bd125ebb9

RESEARCH PRODUCT

A New Entry to the Substituted Pyrrolo[3,2-c]quinoline Derivatives of Biological Interest by Intramolecular Heteroannulation of Internal Imines.

Maria Luisa TestaLiliana LamartinaFrancesco Mingoia

subject

NMR chemical shiftsArylOrganic ChemistryQuinolineGeneral MedicineBiochemistryInternal iminesCombinatorial chemistry2-c]quinoline derivativeschemistry.chemical_compoundchemistryIntramolecular forceDrug DiscoveryOrganic chemistryPyrrolo[3Intramolecular heteroannulation

description

New 1,3,4-substituted pyrrolo[3,2-c]quinoline derivatives were synthesised in good yields by oxidative heteroannulation of internal imines starting from easily prepared substituted 5-(2-aminophenyl)pyrroles and commercially available aryl and heteroaryl aldehydes. The reaction occurs as a one-pot process involving an intramolecular acid catalysed reaction.

https://doi.org/10.1002/chin.200443150