6533b7d2fe1ef96bd125ed77

RESEARCH PRODUCT

Binding ability of N-Para-amino-phenylsulfonyl derivatives of amino acids. Potentiometric and spectroscopic studies of Cu(II) complexes

Maciej MakowskiLeslie D. PettitHenryk KozlowskiTeresa Kowalik-jankowskaKrzysztof Pawelczak

subject

chemistry.chemical_classificationPotentiometric titrationchemistry.chemical_elementPeptideBiochemistryNitrogenMedicinal chemistrySulfonamideAmino acidInorganic Chemistrychemistry.chemical_compoundDeprotonationchemistryAmideOrganic chemistryChelation

description

Abstract N-Para-amino-phenylsulfonyl derivatives of amino acids are very effective ligands for Cu(II) ions. Potentiometric and spectroscopic results have shown that Cu(II) ions are able to deprotonate and bind to sulfonamide nitrogen below pH 5 to form stable mono- and bis-[N − , COO − ] chelates. The basicity of sulfonamide nitrogen is lower than peptide amide nitrogen and no distinct anchoring site is necessary to promote the amide nitrogen deprotonation.

yearjournalcountryeditionlanguage
1995-02-15Journal of Inorganic Biochemistry
https://doi.org/10.1016/0162-0134(94)00022-3