6533b7d2fe1ef96bd125f3a0

RESEARCH PRODUCT

ChemInform Abstract: Synthesis and Antineoplastic Activity of New 4-Diazopyrazole Derivatives.

Salvatore PlesciaBenedetta MaggioDemetrio RaffaGiuseppe DaidoneDomenico Schillaci

subject

Nitrous acidChemistryHistiocytic lymphomaStereochemistryGeneral Medicinemedicine.diseaseMolecular biologyIn vitroLymphomachemistry.chemical_compoundCell culturehemic and lymphatic diseasesmedicineGrowth inhibitionChronic myelogenous leukemiaK562 cells

description

Several new 4-diazopyrazole derivatives were synthesized by reaction of 1-(R-substituted)phenyl-3-methyl-5-benzamidopyrazoles with a sevenfold excess of nitrous acid in acetic media. The compounds were tested at 20 microM concentration for their antineoplastic activity in vitro against Raji (human Burkitt lymphoma), K562 (human chronic myelogenous leukemia) and U937 (human histiocytic lymphoma) cell lines. They showed a percent of growth inhibition in the range 23.4-100%.

yearjournalcountryeditionlanguage
2010-06-22ChemInform
https://doi.org/10.1002/chin.199820146