6533b7d2fe1ef96bd125f449
RESEARCH PRODUCT
Cytotoxic Glial Swelling by Arachidonic Acid
J. PetersF. StaubOliver KempskiAndrea Sylvia WinklerAlexander Baethmannsubject
chemistry.chemical_classificationRadicalIschemiaFatty acidPhospholipasemedicine.diseasechemistry.chemical_compoundMembranechemistryBiochemistrymedicineCytotoxic T cellArachidonic acidStearic aciddescription
Arachidonic acid (AA, 20:4) is a major constituent of membrane phospholipids in brain tissue. Normally, the free fatty acid is present only in a small amount, but it accumulates under adverse conditions, such as ischemia or brain injury [1,9]. The release of free fatty acid involves activation of phospholipases and breakdown of membrane phospholipids. AA in particular is considered to mediate pathological processes. The polyunsaturated compound is a precursor of prostaglandins, leukotrienes, and oxygen-derived free radicals [11]. In cerebral ischemia concentrations of free AA of up to 0.5 mM/kg have been found in brain tissue [9].
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-01-01 |