6533b7d2fe1ef96bd125f474
RESEARCH PRODUCT
ChemInform Abstract: Substituent Effect on Oxidative Cyclization of Aldehyde Thiosemicarbazones with Ferric Chloride.
Francesco BuccheriMichelangelo GruttadauriaGiuseppe CusmanoGiuseppe WerberRenato Notosubject
chemistry.chemical_classificationReaction mechanismSubstituentGeneral MedicineRing (chemistry)AldehydeMedicinal chemistryChloridechemistry.chemical_compoundchemistrymedicineFerricOrganic chemistryPhenyl groupReactivity (chemistry)medicine.drugdescription
The reactivity of aldehyde thiosemicarbazones 1 with ferric chloride solutions was examined. When compounds 1 are not substituted on the N-2 nitrogen atom formation of 1,3,4-thiadiazole 3 heterocyclic ring was observed. In contrast 1,2,4-triazoline 4 and/or 1,3,4-thiadiazoline 5 heterocyclic rings were afforded when N-2 nitrogen atom carried a methyl or a phenyl group. The reaction mechanism is also discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-22 | ChemInform |