6533b7d2fe1ef96bd125f4b7
RESEARCH PRODUCT
Chromophobe Renal Cell Carcinoma
M. Gregori-romeroLuisa Morell-quadrenyAntonio Llombart-boschsubject
medicine.medical_specialtyeducation.field_of_studyPathologymedicine.diagnostic_testChromophobe Renal Cell CarcinomaPopulationCytogeneticsCell BiologyBiologymedicine.diseasePathology and Forensic MedicineFlow cytometryCytokeratinRenal cell carcinomaCytoplasmmedicineeducationIntermediate filamentdescription
SUMMARY A case ofchromophobe renal cell carcinoma is reported in a 73 year-old man. Light microscopically, the tumor was composed of polygonal cells with a slightly eosinophilic and a fine reticular pattern, and a reaction of the cytoplasm with Hale's acid iron colloid. Ultrastructural analysis showed membranous microuesicles within the tumor cells, with degenerated mitochondria. Immunohistochemical profile against intermediate filaments was positive to cytokeratin 18 and negative against uimentin. Flow cytometry and cytogenetics revealed a predominant bypertriploid population. Few cases have been published with flow cytometry and cytogenetic findings. We report a new case.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-01-01 | Pathology - Research and Practice |