Can neurophysiological markers of anticipation and attention predict ADHD severity and neurofeedback outcomes?

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RESEARCH PRODUCT

Can neurophysiological markers of anticipation and attention predict ADHD severity and neurofeedback outcomes?

Sabina Millenet Pascal M Aggensteiner Christian Ruckes Sarah Hohmann Aribert Rothenberger Björn Albrecht Björn Albrecht Christine M. Freitag Ute Strehl Daniel Brandeis Tanja Legenbauer Sonja Wörz Martin Holtmann Holger Gevensleben Tobias Banaschewski

subject

medicine.medical_specialty Brain activity and meditation medicine.medical_treatment Audiology Biofeedback law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Continuous performance task Event-related potential law medicine Humans Attention Child medicine.diagnostic_test business.industry General Neuroscience Electroencephalography Neurofeedback Anticipation 030227 psychiatry Contingent negative variation Neuropsychology and Physiological Psychology Attention Deficit Disorder with Hyperactivity Neurofeedback Cues business 030217 neurology & neurosurgery

description

Abstract Neurophysiological measures of preparation and attention are often atypical in ADHD. Still, replicated findings that these measures predict which patients improve after Neurofeedback (NF), reveal neurophysiological specificity, and reflect ADHD-severity are limited. Methods We analyzed children’s preparatory (CNV) and attentional (Cue-P3) brain activity and behavioral performance during a cued Continuous Performance Task (CPT) before and after slow cortical potential (SCP)-NF or semi-active control treatment (electromyogram biofeedback). Mixed-effects models were performed with 103 participants at baseline and 77 were assessed for pre-post comparisons focusing on clinical outcome prediction, specific neurophysiological effects of NF, and associations with ADHD-severity. Results Attentional and preparatory brain activity and performance were non-specifically reduced after treatment. Preparatory activity in the SCP-NF group increased with clinical improvement. Several performance and brain activity measures predicted non-specific treatment outcome. Conclusion Specific neurophysiological effects after SCP-NF were limited to increased neural preparation associated with improvement on ADHD-subscales, but several performance and neurophysiological measures of attention predicted treatment outcome and reflected symptom severity in ADHD. The results may help to optimize treatment.

year	journal	country	edition	language
2021-10-01	Biological psychology

10.1016/j.biopsycho.2021.108169 https://pubmed.ncbi.nlm.nih.gov/34416347