Germinal center B cells govern their own fate via antibody feedback

6533b7d2fe1ef96bd125f67f

RESEARCH PRODUCT

Germinal center B cells govern their own fate via antibody feedback

Mahmood Khan Clare A. Notley Marc Thilo Figge Margaret Goodall Francesco Falciani Kai-michael Toellner Michael Meyer-hermann Laura A. George Adam Reynolds Yang Zhang Michael R. Ehrenstein Stephen P. Young Ari Waisman Marie Kosco-vilbois

subject

endocrine system Immunology B-cell receptor Antibody Affinity Plasma cell Biology Antibodies Affinity maturation Mice 03 medical and health sciences 0302 clinical medicine health services administration polycyclic compounds medicine Animals Immunology and Allergy Cell Lineage Antigen-presenting cell 030304 developmental biology B-Lymphocytes 0303 health sciences B cell selection Brief Definitive Report Germinal center Germinal Center Molecular biology 3. Good health Mice Inbred C57BL B-1 cell medicine.anatomical_structure Polyclonal B cell response sense organs hormones hormone substitutes and hormone antagonists Dendritic Cells Follicular 030215 immunology

description

High-affinity antibodies reenter germinal centers (GCs) and limit antigen access, thus causing sustained directional evolution in GCs toward higher-affinity antibody production.

year	journal	country	edition	language
2013-02-18	Journal of Experimental Medicine

https://doi.org/10.1084/jem.20120150

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