6533b7d2fe1ef96bd125f6ad
RESEARCH PRODUCT
A Modular Access to (±)-Tubocurine and (±)-Curine - Formal Total Synthesis of Tubocurarine.
Dorota FerencTill OpatzNicola Ottosubject
Molecular Structure010405 organic chemistryStereochemistryChemistryAlkaloidOrganic ChemistryCurare alkaloidsChemistry OrganicTotal synthesisTubocurarine010402 general chemistryIsoquinolines01 natural sciencesCatalysis0104 chemical sciencesTubocurineBenzaldehydesCopperdescription
Two consecutive Cu-catalyzed Ullmann-type C–O couplings permitted the first successful entry toward the curare alkaloids (±)-tubocurine and (±)-curine. Starting from vanillin, the synthetic sequence comprises 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-05 | The Journal of organic chemistry |