Requirements for Th1-dependent immunity against infection with Leishmania major

6533b7d2fe1ef96bd125f708

RESEARCH PRODUCT

Requirements for Th1-dependent immunity against infection with Leishmania major

Mark C. Udey Esther Von Stebut

subject

Cellular immunity Immunology Leishmaniasis Cutaneous Biology Microbiology Mice Immune system Cutaneous leishmaniasis Immunity medicine Animals Humans Leishmania major Leishmania major Antigen Presentation Mice Inbred BALB C Dendritic Cells Dendritic cell Th1 Cells biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Leishmania Mice Inbred C57BL Infectious Diseases Immunology Interleukin 12

description

Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.

year	journal	country	edition	language
2004-10-01	Microbes and Infection

https://doi.org/10.1016/j.micinf.2004.05.024

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