6533b7d2fe1ef96bd125f726
RESEARCH PRODUCT
EXTRACELLULAR VESCICLES DERIVED FROM GUT MICROBIOTA IN INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER
Giusi AlbertiMargherita MazzolaFrancesco CariniCarola Maria GagliardoMarco GiammancoAlberto FucariniAlessandro PitruzzellaGiovanni Tomasellosubject
Colorectal cancerGut microbiotaGut floraInflammatory bowel diseaseInflammatory bowel diseaseGeneral Biochemistry Genetics and Molecular BiologyExtracellular VesiclesImmune systemFlora (microbiology)HumansMedicineMicrobiomeBarrier functionBacteriabiologybusiness.industryMicrobiotaRInflammatory Bowel Diseasesmedicine.diseasebiology.organism_classificationColorectal cancerdigestive system diseasesGastrointestinal MicrobiomeCrosstalk (biology)ImmunologyMedicinecolo-rectal cancer extracellular vescicles gut microbiota inflammatory bowel dseaseColorectal Neoplasmsbusinessdescription
The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-micro-organism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dys-regulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs may have in IBD and CRC, and discusses the possible use of EVs derived from intestinal microbiota in therapeutic strategies for treating these conditions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-09-01 |