6533b7d2fe1ef96bd125f833
RESEARCH PRODUCT
Expression of IAPs and alternative splice variants in hepatocellular carcinoma tissues and cells.
Giuseppe MontaltoMaria MeliLuisa DusonchetMonica NotarbartoloLydia GiannitrapaniNatale D'alessandroMelchiorre CervelloPaola Pomasubject
Carcinoma HepatocellularApoptosisX-Linked Inhibitor of Apoptosis ProteinBiologyBioinformaticsGeneral Biochemistry Genetics and Molecular BiologyHistory and Philosophy of ScienceCell Line TumorSurvivinCarcinomamedicineHumansspliceRNA MessengerCell ProliferationCell growthReverse Transcriptase Polymerase Chain ReactionGeneral NeuroscienceAlternative splicingLiver NeoplasmsIntracellular Signaling Peptides and ProteinsProteinsmedicine.diseasePrognosisXIAPbody regionsAlternative SplicingApoptosisDrug Resistance NeoplasmHepatocellular carcinomaCancer researchdescription
IAPs (inhibitors of apoptosis proteins) might have a major role in the apoptotic resistance that marks many cancers. The studies on IAPs in human HCC have focused on survivin or XIAP, indicating that their new or increased expression in this tumor is associated with a more unfavorable prognosis. The present results corroborate these findings, emphasizing the role that the coordinated expression of different IAPs and alternative splice variants might play in the adverse biology of hepatocellular carcinoma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-01-15 | Annals of the New York Academy of Sciences |