6533b7d3fe1ef96bd125ffe9

RESEARCH PRODUCT

A case control study of statin and magnesium administration in patients after aneurysmal subarachnoid hemorrhage: incidence of delayed cerebral ischemia and mortality

Thomas KerzRobert ReischAnja VictorFlorian HeidChristian BeyerInka Trapp

subject

MaleSimvastatinStatinSubarachnoid hemorrhagemedicine.drug_classIschemia610 Medicine & healthBrain Ischemia10180 Clinic for NeurosurgeryStatistical significancemedicineHumansMagnesiumcardiovascular diseasesRetrospective Studiesbusiness.industryIncidence (epidemiology)Anticholesteremic AgentsCase-control studynutritional and metabolic diseasesGeneral MedicineMiddle AgedSubarachnoid Hemorrhagemedicine.diseaseSurvival RateTreatment Outcome2728 Neurology (clinical)NeurologySimvastatinAnesthesiaCase-Control Studies2808 Neurologylipids (amino acids peptides and proteins)Observational studyFemaleNeurology (clinical)businessmedicine.drug

description

To analyse the effect of the implementation of statin and magnesium treatment on delayed cerebral ischemia (DCI) and 14 day mortality in patients with subarachnoid hemorrhage (SAH).Retrospective, single-center, observational case control study. One hundred SAH patients received either simvastatin and magnesium, solely statin or no treatment.Eighteen percent (n=5) of patients receiving statin and magnesium treatment developed a DCI whereas 24% (n=5) in the statin group and 16% (n=8) in the control group had DCI. Dead by day 14 was registered in 18% (n=5) of patients in the statin and magnesium group, in 10% (n=2) in the statin group and in 27% (n=14) in the control group. None of the results reached a statistical significance level of 0.05.A trend towards a lower mortality within 14 days in patients receiving solely simvastatin and those receiving statin and magnesium as compared with the control group was found. A higher incidence for DCI was found in the statin group, whereas patients without statin and magnesium tended to have less often DCI. None of the results was statistically significant.

yearjournalcountryeditionlanguage
2008-11-01
10.5167/uzh-15845https://www.zora.uzh.ch/id/eprint/15845/