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RESEARCH PRODUCT
Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation
Matthias SchaeferGunter ReuterAnn E. Ehrenhofer-murrayTomasz P. JurkowskiWolfgang NellenSerge AnkriMark HelmFrank LykoAlbert Jeltschsubject
0301 basic medicineRetroelementsRNA methylationChemical biologyReviewBiologyMethylationCatalysisEpigenesis GeneticSubstrate Specificity03 medical and health scienceschemistry.chemical_compoundStructure-Activity RelationshipNucleic AcidsAnimalsHumansEpigeneticsDNA (Cytosine-5-)-MethyltransferasesGene SilencingMolecular BiologytRNAPhylogenyGeneticsNucleic acid methylationDNA methylationBinding SitesepigeneticsCell BiologyTRNA Methyltransferasesmethylcytidine030104 developmental biologyCell Transformation NeoplasticBiochemistrychemistryStructural biologyGene Expression RegulationNucleic acidRNA methylationDNAProtein Bindingdescription
ABSTRACT A group of homologous nucleic acid modification enzymes called Dnmt2, Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a methyl group from the cofactor S-adenosyl-methionine (SAM) to the carbon-5 of cytosine residues. Originally considered as DNA MTases, these enzymes were shown to be tRNA methyltransferases about a decade ago. Between the presumed involvement in DNA modification-related epigenetics, and the recent foray into the RNA modification field, significant progress has characterized Dnmt2-related research. Here, we review this progress in its diverse facets including molecular evolution, structural biology, biochemistry, chemical biology, cell biology and epigenetics.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-05-01 | RNA Biology |