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RESEARCH PRODUCT

Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts

Daniela ZugnaJohn PendersLorenzo RichiardiClaudia GalassiAgnes M.m. Sonnenschein-van Der VoortUlrike SteuerwaldIsabella Annesi-maesanoSofia CorreiaHenrique BarrosFrancesco ForastiereMikel BasterrecheaNour BaïzPernille Stemann LarsenMaria Skaalum PetersenJordi SunyerMartine VrijheidMaria Pia FantiniAnne-marie Nybo AndersenMonique MommersHazel InskipAna EspluguesFranca RusconiDaniela PortaMireia GasconMaties TorrentDavide GoriKatharine C. PikeLiesbeth Duijts

subject

PediatricsPRESCHOOL-CHILDRENEpidemiologyPREPREGNANCY OBESITYINFANTSOverweightDISEASEBody Mass IndexPregnancyRisk FactorsGestational diabetes; Obesity; Overweight; Pre-eclampsia; Pregnancy induced hypertension; Birth Weight; Body Mass Index; Diabetes Gestational; Female; Humans; Hypertension; Obesity; Overweight; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Prevalence; Risk Factors; Respiratory Sounds; Epidemiology; Medicine (all)PrevalenceBirth WeightGestational diabetes2. Zero hungerGESTATIONAL WEIGHT-GAINRISKMedicine (all)DiabetesGeneral Medicine3. Good healthGestational diabetesGestational diabeteGestationalHypertensionGROWTHGeneration RFemalemedicine.symptommedicine.medical_specialtyOffspringBirth weightEARLY-LIFEmedicineHumansPregnancy induced hypertensionObesityRespiratory SoundsPregnancyOVERWEIGHTbusiness.industryASTHMA SYMPTOMSOverweightmedicine.diseasePregnancy ComplicationsDiabetes GestationalRelative riskGENERATION RbusinessBody mass indexPre-eclampsia

description

Background: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient. Methods: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index >= 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model. Results: The study included 85 509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P = 0.027). Conclusions: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.

yearjournalcountryeditionlanguage
2015-02-01International Journal of Epidemiology
10.1093/ije/dyu260https://doi.org/10.1093/ije/dyu260