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RESEARCH PRODUCT
Investigating the association between cancer and the risk of dementia: Results from the Memento cohort
Mathieu CeccaldiAudrey GabelleBruno DuboisCarole DufouilDavid WallonOlivier HanonArmelle GentricPierre Krolak-salmonYannick BéjotGeneviève ChêneOlivier GodefroyJonviea D ChamberlainJonviea D ChamberlainAnaïs RouanetFlorence Pasquiersubject
Malemedicine.medical_specialtymedia_common.quotation_subjectNeuropsychological Testsillness-death modelCohort Studies03 medical and health sciencesCellular and Molecular Neuroscienceillness‐death model0302 clinical medicineDevelopmental NeuroscienceInternal medicineNeoplasmsEpidemiologymedicineDementiaHumanscancerCognitive Dysfunctionselection bias030212 general & internal medicine[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]MortalityResearch Articlesmedia_commonAgedSelection biasbusiness.industryHealth PolicyHazard ratioCancerCognitionAlzheimer's diseasemedicine.diseaseConfidence interval3. Good healthPsychiatry and Mental healthCohortFemaleepidemiology[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Neurology (clinical)FranceGeriatrics and Gerontologybusiness030217 neurology & neurosurgeryResearch Articledementiadescription
International audience; IntroductionStudies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding.MethodsThis study uses data from the Memento cohort, a French multicenter cohort following persons with either mild or isolated cognitive complaints for a median of 5 years. Illness‐death models (IDMs) were used to estimate transition‐specific hazard ratios (HRs) and 95% confidence intervals (CIs) for incident cancer in relation to dementia from time since study entry.ResultsThe analytical sample (N = 2258) excluded 65 individuals without follow‐up information. At the end of follow‐up, 286 individuals were diagnosed with dementia, 166 with incident cancer, and 95 died. Incident cancer was associated with a reduced risk of dementia (HR = 0.58, 95% CI = 0.35‐0.97), with a corresponding E‐value of 2.84 (lower CI = 1.21).DiscussionThis study supports a protective relationship between incident cancer and dementia, encouraging further investigations to understand potential underlying mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-01 |