6533b7d3fe1ef96bd1260bf5

RESEARCH PRODUCT

The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects

Giovanni DavìCustro NSalvatore NovoA. StranoA. Mattina

subject

AdultMalemedicine.medical_specialtyTime Factorsmedicine.drug_classThromboxaneAlpha (ethology)Prostacyclin6-Ketoprostaglandin F1 alphaInternal medicinemedicineHumansCyclooxygenase InhibitorsBlood CoagulationWhole bloodAspirinAspirinChemistryAnticoagulantLow doseThromboxanesHematologyHeparinEpoprostenolThromboxane B2EndocrinologyFemalelipids (amino acids peptides and proteins)circulatory and respiratory physiologymedicine.drug

description

SummaryThe effects of two low doses of aspirin (20 mg and 100 mg) on prostacyclin and thromboxane formation during whole blood clotting were studied in 8 healthy volunteers.A single 100 mg aspirin dose caused more than 90% reduction of both serum TXB2 and 6-keto-PGF1α; a single 20 mg dose of aspirin inhibited serum TXB2 more than 6-keto-PGF1α but effects on these two products could not be completely dissociated.However, the effect of a single 20 mg aspirin dose on serum TXB2, was of much longer duration than its inhibitory effect on PGI2 synthesis during whole blood clotting.

yearjournalcountryeditionlanguage
1983-10-31
http://www.scopus.com/inward/record.url?eid=2-s2.0-0021065859&partnerID=MN8TOARS