6533b7d3fe1ef96bd1260c49
RESEARCH PRODUCT
Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder
Carmen Puig-alcarazJesús CalderónOmar CauliMilagros Fuentes-alberoDolores Garrotesubject
Malemedicine.medical_specialtyPediatricsAdolescentHomocysteineAutism Spectrum DisorderUrinary systembehavioral disciplines and activitieschemistry.chemical_compoundMethioninemental disordersmedicineHumansClinical significanceChildPsychiatryHomocysteineBiological PsychiatryMethioninemedicine.diseaseGlutathioneDiagnostic and Statistical Manual of Mental DisordersPsychiatry and Mental healthchemistryAutism spectrum disorderChild PreschoolCommunication DisordersTyrosineBiomarker (medicine)AutismFemaleCore symptomsPsychologyBiomarkersdescription
The clinical significance of high levels of homocysteine in autism spectrum disorder (ASD) is unknown. An experimental study was conducted in order to evaluate the concentration of homocysteine in children with ASD and typically developing children and to analyse any relationships with the severity of core symptoms of ASD and other clinical features (drugs, co-morbidities, gender, age, diet). Core symptoms of autism were evaluated by DSM-IV criteria. Homocysteine, glutathione, methionine, 3-nitrotyrosine were measured in urine. The increase in homocysteine concentration was significantly and directly correlated with the severity of the deficit in communication skills, but was unrelated to deficit in socialisation or repetitive/restricted behaviour. Urinary homocysteine concentration may be a possible biomarker for communication deficits in ASD and a potential diagnostic tool useful to evaluate new treatment options since no treatment for core symptoms of ASD are available.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-10-01 | Psychiatry Research |