6533b7d3fe1ef96bd1260c80

RESEARCH PRODUCT

Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity

Gomotsang BojaseRunner R. T. MajindaJapheth O. OmbitoAnja SchüfflerIshmael B. MasesaneTill Opatz

subject

ButinTraditional medicinebiologyGeneral Chemical Engineering02 engineering and technologyGeneral ChemistryIsoflavones010402 general chemistry021001 nanoscience & nanotechnologybiology.organism_classification01 natural sciences0104 chemical scienceslcsh:Chemistrychemistry.chemical_compoundchemistrylcsh:QD1-999Cell cultureIc50 valuesCytotoxic T cellErythrina sacleuxii0210 nano-technologyCytotoxicityHuman cancer

description

Two previously undescribed isoflavones, erysacleuxin C (1) and erysacleuxin D (2), together with seven known compounds (3–9), were isolated and identified from the EtOAc extract of the twigs of Erythrina sacleuxii Hua (Leguminosae). The structures of the isolated compounds were determined on the basis of their spectroscopic and spectrometric data. Evaluation of their cytotoxicity against the human cancer HeLa-S3 cell lines indicated IC50 values of 130.4, 54.9 and 73.9 µM for erysacleuxin C (1), erysacleuxin D (2) and butin (9), respectively. Keywords: Erythrina sacleuxii, Leguminosae, Isoflavone, Erysacleuxin C, Erysacleuxin D, Cytotoxicity

yearjournalcountryeditionlanguage
2020-02-01Arabian Journal of Chemistry
10.1016/j.arabjc.2019.05.007http://www.sciencedirect.com/science/article/pii/S187853521930053X