6533b7d3fe1ef96bd12610c5

RESEARCH PRODUCT

PRELIMINARY-OBSERVATIONS OF METABOLIC CHARACTERIZATION OF BILATERAL TEMPORAL EPILEPTIC FOCUS, USING PROTON MAGNETIC-RESONANCE SPECTROSCOPY - 3 CASES

Maurice GiroudPaul WalkerDavid BernardHervé FayolleJacques BeaurainNathalie BaudouinFrançois BrunotteRoland Dumas

subject

PROTON SPECTROSCOPY[ INFO.INFO-IM ] Computer Science [cs]/Medical ImagingN-ACETYL-ASPARTATE[INFO.INFO-IM]Computer Science [cs]/Medical Imaging[INFO.INFO-IM] Computer Science [cs]/Medical ImagingTEMPORAL SEIZURES

description

International audience; Abstract: The authors report the case of 3 patients with bilateral temporal lobe epilepsy demonstrated by EEG and sphenoidal electrodes. Two out of the 3 patients presented with childhood febrile convulsions. Their neurological and mental examination was normal. EEG showed spikes within the anterior part of the 2 temporal lobes. CT scan and MRI showed no atrophic lesion within the 2 temporal lobes. Proton magnetic resonance spectroscopy, performed within a cube of 8 cube-centimetres localized in the anterior part of the 2 temporal lobes showed a significant decrease of N-acetyl-aspartate in the 2 temporal lobes of the 3 cases, compared with controls matched with age, sex and laterality. Because N-acetyl-aspartate is a marker of the neuronal cells, the decreased level of NAA in the temporal area with spikes, may be rebated to a decreased number of neuronal cells, developing an abnormal tendency to seizures.

yearjournalcountryeditionlanguage
1994-12-01
https://hal.science/hal-00790134