6533b7d3fe1ef96bd1261413
RESEARCH PRODUCT
Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology
Nicola AmodioGiuseppe VigliettoElisa TaianaAngela De LucaAntonino NeriRiccardo AlessandroRiccardo AlessandroGianluca GiavaresiStefania RaimondoAlessia GalloLavinia RaimondiMarco Rossisubject
0301 basic medicinelcsh:QH426-470Bone diseasenon-coding RNAReviewBiologyBiochemistryBone remodeling03 medical and health sciences0302 clinical medicineOsteoclastmicroRNAGeneticsmedicinetumor microenvironmentMolecular BiologyMultiple myelomamiRNAlong non-coding RNAmedicine.diseaseNon-coding RNALong non-coding RNAmultiple myelomalcsh:Genetics030104 developmental biologymedicine.anatomical_structure030220 oncology & carcinogenesisCancer researchbone diseaseBone marrowdescription
Bone remodeling is uncoupled in the multiple myeloma (MM) bone marrow niche, resulting in enhanced osteoclastogenesis responsible of MM-related bone disease (MMBD). Several studies have disclosed the mechanisms underlying increased osteoclast formation and activity triggered by the various cellular components of the MM bone marrow microenvironment, leading to the identification of novel targets for therapeutic intervention. In this regard, recent attention has been given to non-coding RNA (ncRNA) molecules, that finely tune gene expression programs involved in bone homeostasis both in physiological and pathological settings. In this review, we will analyze major signaling pathways involved in MMBD pathophysiology, and report emerging evidence of their regulation by different classes of ncRNAs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-01 | Non-Coding RNA |