6533b7d3fe1ef96bd1261446
RESEARCH PRODUCT
A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: does the ratio really matter?
Sabrina CastellanoFabio GalvanoSilvio BuscemiAntonio MistrettaGiuseppe GrossoStefano MarventanoPaulina Kolaczsubject
medicine.medical_specialtyN 6 pufachronic diseases inflammation polyunsaturated fatty acidsDiseaseBiologyBioinformaticsHuman healthInternal medicineFatty Acids Omega-6NeoplasmsFatty Acids Omega-3medicineHumansSettore MED/49 - Scienze Tecniche Dietetiche ApplicateDepression (differential diagnoses)chemistry.chemical_classificationDepressive DisorderHuman studiesfood and beveragesCancermedicine.diseaseEndocrinologychemistryCardiovascular Diseaseslipids (amino acids peptides and proteins)Food AnalysisFood SciencePolyunsaturated fatty aciddescription
AbstractPolyunsaturated fatty acids (PUFAs) have been considered of great interest for human health due to their potential anti-inflammatory action that may protect from a number of chronic-degenerative diseases with an inflammatory pathogenesis. This review aimed to report the most updated evidence of both n-3 and n-6 PUFAs effect on cardiovascular disease, cancer, and depression in humans. Attention has been also paid to those studies exploring the effects of the ratio intake. Results from pooled analyses of human studies reported a general positive effect of n-3 PUFAs intake on all outcomes considered. In contrast, the role of n-6 PUFAs on human health needs to be better assessed in order to clearly identify which compound exerts beneficial/harmful effects. Only a limited number of clinical studies considered the n-3:n-6 PUFAs ratio, rather reporting contrasting results. A number of limitations when considering the ratio between these two families of PUFAs have risen.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | International journal of food sciences and nutrition |