6533b7d3fe1ef96bd1261484
RESEARCH PRODUCT
Effects of high doses of toluene on color vision.
Volkmar WoltersAxel MuttrayDetlev JungJohannes Konietzkosubject
AdultMalemedicine.medical_specialtygenetic structuresColor visionToxicologyOptic neuropathyCellular and Molecular Neurosciencechemistry.chemical_compoundDevelopmental NeuroscienceOphthalmologyOccupational ExposureHigh dosesMedicineHumansDyschromatopsiaToluene toxicitybusiness.industrymedicine.diseaseTolueneSurgerychemistryAcute exposurePrintingbusinessColor PerceptionRetinopathyToluenedescription
High exposure to toluene may cause optic neuropathy and retinopathy, both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue-yellow dyschromatopsia. This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined before and after cleaning printing containers with pure toluene. After cleaning, concentrations of toluene in blood were between 3.61 and 7.37 mg/l. Color vision was tested with the Farnsworth panel D-15 test, the Lanthony desaturated panel D-15 test, and the Standard Pseudoisochromatic Plates part 2. For control of possible acute effects, eight workers of a metal-working factory without any neurotoxic exposure were tested according to the same procedure. Acute exposure to toluene did not cause impairment of color vision. However, statistical power is limited due to the small number of exposed subjects. Color vision of the printshop workers tested before cleaning was slightly impaired (statistically not significant) when compared with unexposed subjects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-02-19 | Neurotoxicology and teratology |