6533b7d3fe1ef96bd1261511

RESEARCH PRODUCT

Hybrid assemblies based on a gadolinium-containing polyoxometalate and a cationic polymer with spermine side chains for enhanced MRI contrast agents.

Shan WangManfred SchmidtLixin WuHang ZhaoGuifeng LiuWenqiang ChaiKarl FischerHaolong Li

subject

BiocompatibilityPolymersGadoliniumOrganic ChemistryInorganic chemistryCationic polymerizationchemistry.chemical_elementContrast MediaGadoliniumGeneral ChemistryTungsten CompoundsCombinatorial chemistryMagnetic Resonance ImagingCatalysisSupramolecular assemblychemistryCationsPolyoxometalateSide chainSpermineSelf-assemblyHybrid material

description

Supramolecular assembly: Spherical and stable hybrid assemblies based on a cationic polymer with spermine side chains and an anionic Gd(3+)-containing polyoxometalate cluster (GdW) are prepared by electrostatic interaction. The T1-weighted MRI performance of GdW is enhanced about three times in the assemblies; meanwhile, the assemblies show good biocompatibility, which enables them to be promising candidates for MRI contrast agents.

yearjournalcountryeditionlanguage
2013-07-05Chemistry (Weinheim an der Bergstrasse, Germany)
10.1002/chem.201302618https://pubmed.ncbi.nlm.nih.gov/24030934