6533b7d3fe1ef96bd1261568

RESEARCH PRODUCT

Influence of digoxin on sinus node function after pharmacologic autonomic blockade.

T. McinertzGilfrich HjWolfgang KasperTiberius PopNorbert Treese

subject

AdultAtropineMaleDigoxinDigoxinPropranololTherapeutic indexDrug DiscoveryAutonomic blockademedicineAtropine sulfateHumansCycle lengthGenetics (clinical)AgedSinoatrial NodeChemistryGeneral MedicineMiddle AgedPropranololSinus node functionAnesthesiaMolecular MedicineFemalemedicine.drugSinoatrial conduction

description

The effect of iv digoxin on normal sinus node function was studied after pharmacologic autonomic blockade (AB) in ten patients. Sinus cycle length (SCL), sinus node recovery time (SNRT) and sinoatrial conduction time (SACT) were determined before and after AB with propranolol (0.2 mg/kg body weight) and atropine sulfate (0.04 mg/kg body weight) iv, and 15 min, 30 min, and 45 min after 1 mg iv digoxin. AB resulted in a significant decrease (P less than 0.01) in SCL (916 +/- 158 to 716 +/- 120 ms), in SNRT (1,229 +/- 221 to 871 +/- 190 ms), and in SACT (79 +/- 34 to 44 +/- 10 ms). Fifteen minutes after iv digoxin there was no significant change observed in SCL (716 +/- 120 to 708 +/- 92 ms), in SNRT (871 +/- 190 to 864 +/- 148 ms), or in SACT (44 +/- 10 to 46 +/- 15 ms). Similar results were obtained 30 min after digoxin administration. It is concluded that a single therapeutic dose of digoxin has no direct effect on electrophysiologic parameters of normal intrinsic sinus node function.

yearjournalcountryeditionlanguage
1983-05-16Klinische Wochenschrift
10.1007/bf01488720https://pubmed.ncbi.nlm.nih.gov/6876685