Does catalase play a role in Adriamycin induced cardiotoxicity?

6533b7d3fe1ef96bd12615bc

RESEARCH PRODUCT

Does catalase play a role in Adriamycin induced cardiotoxicity?

L. Crosta Natale D'alessandro Marilena Crescimanno Luciano Rausa Luisa Dusonchet

subject

chemistry.chemical_classification Pharmacology Cardiotoxicity Lipid Peroxides biology Free Radicals Heart Diseases Myocardium Pharmacology NAD Catalase Malonates carbohydrates (lipids)Lipid peroxidation chemistry.chemical_compound Mice Enzyme chemistry Catalase Doxorubicin Malondialdehyde polycyclic compounds biology.protein Animals Female

description

Summary Adriamycin causes an increase of lipid peroxidation in mouse cardiac homogenates that is dependent on the concentration of the antiblastic. The same phenomenon is not observed in the hearts of mice treated with an elevated dose of Adriamycin in which, conversely, an increase of the antioxidizing enzyme catalase was noticed. The significance of these findings is discussed with relationship to the hypothesis of an enhanced free radicals formation at the basis of Adriamycin induced cardiotoxicity.

year	journal	country	edition	language
1980-05-01	Pharmacological Research Communications

https://doi.org/10.1016/s0031-6989(80)80114-7

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