6533b7d3fe1ef96bd1261690
RESEARCH PRODUCT
2-Alkenoyl Pyridine N-Oxides, Highly Efficient Dienophiles for the Enantioselective Cu(II)−Bis(oxazoline) Catalyzed Diels−Alder Reaction
Gonzalo BlayJosé R. PedroSantiago Barrososubject
PyridinesCyclopentanesOxazolineAlkenesMedicinal chemistryBiochemistryCatalysisCatalysischemistry.chemical_compoundChalconeIsomerismPyridineOrganic chemistryReactivity (chemistry)Physical and Theoretical ChemistryOxazolesDiels–Alder reactionchemistry.chemical_classificationAza CompoundsMolecular StructureChemistryOrganic ChemistryEnantioselective synthesisGeneral MedicineBridged compoundsCopperdescription
2-Alkenoyl pyridine N-oxides are introduced as a new kind of efficient dienophiles for the Cu(II)−bis(oxazoline) (BOX) catalyzed enantioselective Diels−Alder reaction affording higher reactivity and enantioselectivity (ee's up to 96%) than the corresponding nonoxidized 2-alkenoyl pyridines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-04-24 | Organic Letters |