ChemInform Abstract: Enantioselective Zinc-Mediated Conjugate Addition of Terminal Alkynes to Enones.

6533b7d4fe1ef96bd1261d01

RESEARCH PRODUCT

ChemInform Abstract: Enantioselective Zinc-Mediated Conjugate Addition of Terminal Alkynes to Enones.

Amparo Sanz-marco Gonzalo Blay Luz Cardona José R. Pedro

subject

Addition reaction chemistry.chemical_compound Chemistry Yield (chemistry)Enantioselective synthesis chemistry.chemical_element General Medicine Zinc Diethylzinc Enantiomer Combinatorial chemistry Catalysis Conjugate

description

Zinc for conjugate alkynylation: The enantioselective conjugate addition of terminal alkynes to 2-arylidene-1,3-diketones in the presence of diethylzinc and a catalytic amount of (R)-VANOL has been developed. The reaction can be applied to different aromatic and heteroaromatic alkynes and enones, giving the expected products in good yield and with enantiomeric excesses up to 91%. The products can be enantiomerically enriched up to 99% ee by crystallization (see scheme).

year	journal	country	edition	language
2013-02-26	ChemInform

https://doi.org/10.1002/chin.201309063

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