6533b7d4fe1ef96bd1261ddc

RESEARCH PRODUCT

B8, DR3 antigens and production of human leucocyte migration inhibitory factor (LIF) by mononuclear cells stimulated with concanavalin A (Con A)

Calogero CarusoLivia Bellina

subject

Leukocyte Migration-Inhibitory FactorsImmunologyHuman leukocyte antigenInhibitory postsynaptic potentialBiochemistryPeripheral blood mononuclear cellMonocytesHLA-B8 AntigenHLA-DR3 AntigenImmune systemAntigenHLA AntigensConcanavalin AGeneticsHumansImmunology and AllergyGeneLymphokinesbiologyChemistryHistocompatibility Antigens Class IIGeneral MedicineMolecular biologyConcanavalin AImmunologybiology.proteinLeucocyte migration

description

LIF release by Con A stimulated mononuclear cells was evaluated in 67 randomly selected healthy Sicilians typed for HLA antigens. The results show that B8 and/or DR3 positive subjects release less LIF than negative ones, suggesting that this immunological response might be controlled by HLA-linked immune response (Ir) gene(s).

https://doi.org/10.1111/j.1399-0039.1983.tb01184.x