6533b7d4fe1ef96bd1261e43
RESEARCH PRODUCT
Characterization and Stage-Dependent Lineage Analysis of Intermediate Progenitors of Cortical GABAergic Interneurons
Nobuaki TamamakiShigeyuki EsumiTakaichi FukudaYuchio YanagawaMakoto NasuTatsunori SekiKento MorookaKenji SakimuraKoichiro MiikeTakeshi Kawauchisubject
0301 basic medicineLineage (genetic)Ganglionic eminencelaminar distributionNeurosciences. Biological psychiatry. NeuropsychiatryBiologyInhibitory postsynaptic potential03 medical and health sciences0302 clinical medicinemedicinecortical developmentGABAergic neuron progenitorsProgenitor cellOriginal ResearchGeneral NeuroscienceEmbryonic stem cellCell biology030104 developmental biologymedicine.anatomical_structureCerebral cortexExcitatory postsynaptic potentialGABAergicfate analysis030217 neurology & neurosurgeryNeurosciencelineageRC321-571description
Intermediate progenitors of both excitatory and inhibitory neurons, which can replenish neurons in the adult brain, were recently identified. However, the generation of intermediate progenitors of GABAergic inhibitory neurons (IPGNs) has not been studied in detail. Here, we characterized the spatiotemporal distribution of IPGNs in mouse cerebral cortex. IPGNs generated neurons during both embryonic and postnatal stages, but the embryonic IPGNs were more proliferative. Our lineage tracing analyses showed that the embryonically proliferating IPGNs tended to localize to the superficial layers rather than the deep cortical layers at 3 weeks after birth. We also found that embryonic IPGNs derived from the medial and caudal ganglionic eminence (CGE) but more than half of the embryonic IPGNs were derived from the CGE and broadly distributed in the cerebral cortex. Taken together, our data indicate that the broadly located IPGNs during embryonic and postnatal stages exhibit a different proliferative property and layer distribution.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-07-01 | Frontiers in Neuroscience |