6533b7d4fe1ef96bd1261f04

RESEARCH PRODUCT

Multiple roles for ISWI in transcription, chromosome organization and DNA replication.

John W. TamkunDavide Corona

subject

DNA ReplicationTranscriptional ActivationHMG-boxTranscription GeneticBiophysicsBiologyBiochemistryATP-dependent chromatin remodeling ISWI Transcription Replication Chromosome structureChromatin remodelingChromosomesAdenosine TriphosphateControl of chromosome duplicationStructural BiologyGeneticsNucleosomeAnimalsHumansTranscription factorGeneticsAdenosine TriphosphatasesDNA replicationChromatin Assembly and DisassemblyChromatinSettore BIO/18 - GeneticaGene Expression RegulationOrigin recognition complexTranscription Factors

description

ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.

yearjournalcountryeditionlanguage
2003-07-25Biochimica et biophysica acta
10.1016/j.bbaexp.2003.09.018https://pubmed.ncbi.nlm.nih.gov/15020052