6533b7d4fe1ef96bd1261fea

RESEARCH PRODUCT

Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease

Tanja ZellerFrancisco OjedaStefan BlankenbergMahir KarakasKarl J. LacknerRenate B. SchnabelJulius Nikorowitsch

subject

Malemedicine.medical_specialtymedicine.drug_classHead to headMyocardial Infarctionlcsh:QR1-502030204 cardiovascular system & hematologyBiochemistryArticlelcsh:MicrobiologyCoronary artery disease03 medical and health sciences0302 clinical medicineInternal medicineNatriuretic Peptide BrainTroponin ImedicineNatriuretic peptideHumans030212 general & internal medicineMyocardial infarctioncardiovascular diseasesMolecular BiologyAgedbiologybusiness.industryhigh-sensitivity troponin ITroponin IC-reactive proteinHazard ratioMiddle Agedmedicine.diseasePeptide FragmentsN-terminal pro-brain natriuretic peptideC-Reactive ProteinCohortbiology.proteinCardiologyFemalehigh-sensitivity C-reactive proteinprognosisbusinessBiomarkerscoronary artery diseaseFollow-Up Studies

description

Risk stratification among patients with coronary artery disease (CAD) is of considerable interest to potentially guide secondary preventive therapies. Cardiac troponins as well as C-reactive protein (hsCRP) and natriuretic peptides have emerged as biomarkers for risk stratification. The question remains if one of these biomarkers is superior in predicting adverse outcomes. Thus, we perform a head-to-head comparison between high-sensitivity troponin I (hsTnI), hsCRP, and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with CAD. Plasma levels were measured in a cohort of 2193 patients with documented CAD. The main outcome measures were cardiovascular (CV) death and/or nonfatal myocardial infarction (MI). During a median follow-up of 3.8 years, all three biomarkers were associated with cardiovascular death and/or MI. After adjustments for conventional cardiovascular risk factors, the hazard ratio (HR) per standard deviation (SD) for the prediction of CV death and/or nonfatal MI was 1.39 [95% CI: 1.24&ndash

yearjournalcountryeditionlanguage
2020-03-01Biomolecules
10.3390/biom10030394http://dx.doi.org/10.3390/biom10030394