6533b7d4fe1ef96bd1262062
RESEARCH PRODUCT
Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues.
Karl DhaeneThorsten KlampJochen SchwendemannUgur SahinBruno KyewskiÖZlem Türecisubject
Immune Tolerance/geneticsThymus Gland/immunologyTranscription GeneticImmunologyTranscription Genetic/immunologyThymus GlandBiologyLymph Nodes/immunologymedicine.disease_causeAutoimmunityImmune toleranceCell Line TumorNeoplasmsmedicineTranscriptional regulationImmune ToleranceImmunology and AllergyHumansRNA MessengerPolyendocrinopathies AutoimmuneGeneTranscription Factors/biosynthesisAutoimmune diseaseReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingRNA Messenger/biosynthesisDNA Methylationmedicine.diseaseAutoimmune regulatorNeoplasms/geneticsPolyendocrinopathies Autoimmune/geneticsGene expression profilingGene Expression Regulation NeoplasticDNA methylationImmunologyCancer researchLymph NodesGene Expression Profiling/methodsTranscription Factorsdescription
Defects in the autoimmune regulator (AIRE) gene cause the monogenic autoimmune disease autoimmune polyendocrinopathy syndrome type 1 (APS-1), which is characterized by a loss of self-tolerance to multiple organs. In concordance with its role in immune tolerance, AIRE is strongly expressed in medullary thymic epithelial cells (mTECs). Data on mechanisms controlling AIRE activation and the expression of this gene in other tissues are fragmentary and controversial. We report here AIRE mRNA expression profiling of a large set of normal human tissues and cells, tumor specimen and methylation deficient cell lines. On this broad data basis we found that AIRE mRNA expression is confined to mTECs in thymus and to lymph node tissue and that DNA hypomethylation contributes to transcriptional control of this gene.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-08-01 | Immunology letters |