6533b7d4fe1ef96bd126206f
RESEARCH PRODUCT
Vitamin D and Multiple Sclerosis: An Open-Ended Story
Bruna Lo SassoConcetta ScazzoneLuisa AgnelloAnna Maria CiaccioMarcello CiaccioRosaria Vincenza GiglioGiulia Bivonasubject
0301 basic medicinebusiness.industryMultiple sclerosismedicine.diseaseBioinformaticsGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences030104 developmental biology0302 clinical medicineVitamin D Genetic Genes SNP Multiple sclerosis SusceptibilityVitamin D and neurologyMedicineSNPbusiness030217 neurology & neurosurgerydescription
Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease of the Central Nervous System (CNS). Genetic, epigenetic and environmental factors interact together, contributing to the complex pathogenesis of the disease. In the last decades, the role of hypovitaminosis D on MS risk was hypothesised. Several factors drive the regulation of vitamin D status, including genetics. The current review summarises the literature evidence on the association between vitamin D and MS, with a focus on the genetic polymorphisms in vitamin D-related genes. The variants of the genes codifying Vitamin D Receptor (VDR), Vitamin D Binding Protein (VDBP) and CYP enzymes have been investigated, but the findings are controversial. Only a few studies have addressed the role of DHCR7 polymorphisms in MS risk.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-31 |