Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe

6533b7d4fe1ef96bd12620a0

RESEARCH PRODUCT

Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe

M. Moutschen D. Frentz D. A. M. C. Van De Vijver A. B. Abecasis Jan Albert O. Hamouda L. B. Jørgensen C. Ku¨cherer D. Struck J. -C Schmit J. Vercauteren B. A˚sjo¨Claudia Balotta Danail Beshkov Ricardo J. Camacho B. Clotet S. Coughlan A. Griskevicius Z. Grossman A. Horban T. Kolupajeva K. Korn Leontios G. Kostrikis K. Liitsola M. Linka C. Nielsen D. Otelea Dimitrios N. Paraskevis R. Paredes M. Poljak Stockl E. Puchhammer A. So¨nnerborg D. Stanekova M. Stanojevic E. Van Wijngaerden A. M. J. Wensing C. A. B. Boucher Stockl E. Puchhammer M. Sarcletti B. Schmied M. Geit G. Balluch A. -M Vandamme J. Vercauteren I. Derdelinckx A. Sasse M. Bogaert H. Ceunen A. De Roo S. De Wit F. Echahidi K. Fransen J. -C Goffard P. Goubau E. Goudeseune J. -C Yombi P. Lacor C. Liesnard D. Pierard R. Rens Y. Schrooten D. Vaira L. P. R. Vandekerckhove A. Van Den Heuvel B. Van Der Gucht M. Van Ranst E. Van Wijngaerden B. Vandercam M. Vekemans C. Verhofstede N. Clumeck K. Van Laethem Ioannis Demetriades Ioanna Kousiappa Victoria L. Demetriou Johana Hezka M. Bruckova M. Linka L. Machala C. Nielsen L. B. Jørgensen J. Gerstoft L. Mathiesen C. Pedersen H. Nielsen A. Laursen B. Kvinesdal M. Salminen M. Ristola K. Liitsola J. Suni J. Sutinen K. Korn C. Ku¨cherer T. Berg P. Braun G. Poggensee M. Da¨umer J. Eberle H. Heiken R. Kaiser H. Knechten H. Mu¨ller S. Neifer B. Schmidt H. Walter B. Gunsenheimer-bartmeyer T. Harrer Dimitrios N. Paraskevis Angelos E. Hatzakis Emmanouil N. Magiorkinis Eleni Hatzitheodorou Catherine Haida Assimina Zavitsanou Gkikas Magiorkinis Marios C. Lazanas Maria C. Chini N. Magafas Nickolaos Tsogas Vassilios A. Paparizos Sofia Kourkounti Anastasia C. Antoniadou Antonios I. Papadopoulos Periklis Panagopoulos Garyphallia G. Poulakou V. Sakka Georgios Chryssos Stylianos Drimis Panagiotis Gargalianos Moyssis I. Lelekis G. Chilomenos Mina A. Psichogiou George L. Daikos George Panos G. Haratsis Theodore Kordossis Athanasios N. Kontos Georgios Koratzanis Maria C. Theodoridou Glykeria J. Mostrou Vana I. Spoulou S. Coughlan C. De Gascun C. Byrne M. Duffy C. Bergin D. Reidy G. Farrell J. Lambert E. O'connor A. Rochford J. Low P. Coakely S. O'dea W. Hall Z. Grossman I. Levi D. Chemtob Claudia Balotta C. Riva C. Mussini I. Caramma A. Capetti M. C. Colombo C. Rossi F. Prati F. Tramuto F. Vitale M. Ciccozzi G. Angarano G. Rezza J. C. Schmit D. Struck R. Hemmer V. Arendt T. Staub F. Schneider F. Roman A. M. J. Wensing C. A. B. Boucher A. Van Kessel P. H. M. Van Bentum K. Brinkman E. L. Op De Coul M. E. Van Der Ende I. Hoepelman M. Van Kasteren J. Juttmann M. Kuipers N. Langebeek C. Richter R. Santegoets L. Schrijnders-gudde R. Schuurman B. J. M. Van De Ven B. A˚sjo¨V. Ormaasen P. Aavitsland A. Horban J. J. Stanczak G. P. Stanczak E. Firlag-burkacka A. Wiercinska-drapalo E. Jablonowska E. Malolepsza M. Leszczyszyn-pynka W. Szata Ricardo J. Camacho C. Palma F. Borges Paixa&tild T. O V. Duque F. Araújo D. Jevtovic D. Salemovic D. Stanekova M. Habekova Miloš Mokráš P. Truska M. Poljak M. Lunar Dunja Z. Babic J. Tomazic L. Vidmar T. Vovko P. Karner B. Clotet P. Domingo M. J. Galindo C. Miralles M. A. Del Pozo E. Ribera J. A. Iribarren L. Ruiz J. De La Torre F. Vidal F. Garcia R. Paredes Jan Albert A. Heidarian K. Aperia-peipke M. Axelsson M. Mild A. Karlsson A. So¨nnerborg A. Thalme L. Nave´r G. Bratt A. Karlsson A. Blaxhult M. Gissle´n B. Svennerholm I. Bergbrant Per Björkman C. Sa¨ll A˚ Mellgren A. Lindholm N. Kuylenstierna R. Montelius F. Azimi B. Johansson M. Carlsson E. Johansson B. Ljungberg H. Ekvall A. Strand S. Ma¨kitalo S. O¨berg P. Holmblad M. Ho¨fer H. Holmberg P. Josefson U. Ryding M. Moutschen D. Frentz D. A. M. C. Van De Vijver A. B. Abecasis Jan Albert O. Hamouda L. B. Jørgensen C. Ku¨cherer D. Struck J. -C Schmit J. Vercauteren B. A˚sjo¨Claudia Balotta Danail Beshkov Ricardo J. Camacho B. Clotet S. Coughlan A. Griskevicius Z. Grossman A. Horban T. Kolupajeva K. Korn Leontios G. Kostrikis K. Liitsola M. Linka C. Nielsen D. Otelea Dimitrios N. Paraskevis R. Paredes M. Poljak Stockl E. Puchhammer A. So¨nnerborg D. Stanekova M. Stanojevic E. Van Wijngaerden A. M. J. Wensing C. A. B. Boucher Stockl E. Puchhammer M. Sarcletti B. Schmied M. Geit G. Balluch A. -M Vandamme J. Vercauteren I. Derdelinckx A. Sasse M. Bogaert H. Ceunen A. De Roo S. De Wit F. Echahidi K. Fransen J. -C Goffard P. Goubau E. Goudeseune J. -C Yombi P. Lacor C. Liesnard D. Pierard R. Rens Y. Schrooten D. Vaira L. P. R. Vandekerckhove A. Van Den Heuvel B. Van Der Gucht M. Van Ranst E. Van Wijngaerden B. Vandercam M. Vekemans C. Verhofstede N. Clumeck K. Van Laethem Ioannis Demetriades Ioanna Kousiappa Victoria L. Demetriou Johana Hezka M. Bruckova M. Linka L. Machala C. Nielsen L. B. Jørgensen J. Gerstoft L. Mathiesen C. Pedersen H. Nielsen A. Laursen B. Kvinesdal M. Salminen M. Ristola K. Liitsola J. Suni J. Sutinen K. Korn C. Ku¨cherer T. Berg P. Braun G. Poggensee M. Da¨umer J. Eberle H. Heiken R. Kaiser H. Knechten H. Mu¨ller S. Neifer B. Schmidt H. Walter B. Gunsenheimer-bartmeyer T. Harrer Dimitrios N. Paraskevis Angelos E. Hatzakis Emmanouil N. Magiorkinis Eleni Hatzitheodorou Catherine Haida Assimina Zavitsanou Gkikas Magiorkinis Marios C. Lazanas Maria C. Chini N. Magafas Nickolaos Tsogas Vassilios A. Paparizos Sofia Kourkounti Anastasia C. Antoniadou Antonios I. Papadopoulos Periklis Panagopoulos Garyphallia G. Poulakou V. Sakka Georgios Chryssos Stylianos Drimis Panagiotis Gargalianos Moyssis I. Lelekis G. Chilomenos Mina A. Psichogiou George L. Daikos George Panos G. Haratsis Theodore Kordossis Athanasios N. Kontos Georgios Koratzanis Maria C. Theodoridou Glykeria J. Mostrou Vana I. Spoulou S. Coughlan C. De Gascun C. Byrne M. Duffy C. Bergin D. Reidy G. Farrell J. Lambert E. O'connor A. Rochford J. Low P. Coakely S. O'dea W. Hall Z. Grossman I. Levi D. Chemtob Claudia Balotta C. Riva C. Mussini I. Caramma A. Capetti M. C. Colombo C. Rossi F. Prati F. Tramuto F. Vitale M. Ciccozzi G. Angarano G. Rezza J. C. Schmit D. Struck R. Hemmer V. Arendt T. Staub F. Schneider F. Roman A. M. J. Wensing C. A. B. Boucher A. Van Kessel P. H. M. Van Bentum K. Brinkman E. L. Op De Coul M. E. Van Der Ende I. Hoepelman M. Van Kasteren J. Juttmann M. Kuipers N. Langebeek C. Richter R. Santegoets L. Schrijnders-gudde R. Schuurman B. J. M. Van De Ven B. A˚sjo¨V. Ormaasen P. Aavitsland A. Horban J. J. Stanczak G. P. Stanczak E. Firlag-burkacka A. Wiercinska-drapalo E. Jablonowska E. Malolepsza M. Leszczyszyn-pynka W. Szata Ricardo J. Camacho C. Palma F. Borges Paixa&tild T. O V. Duque F. Araújo D. Jevtovic D. Salemovic D. Stanekova M. Habekova Miloš Mokráš P. Truska M. Poljak M. Lunar Dunja Z. Babic J. Tomazic L. Vidmar T. Vovko P. Karner B. Clotet P. Domingo M. J. Galindo C. Miralles M. A. Del Pozo E. Ribera J. A. Iribarren L. Ruiz J. De La Torre F. Vidal F. Garcia R. Paredes Jan Albert A. Heidarian K. Aperia-peipke M. Axelsson M. Mild A. Karlsson A. So¨nnerborg A. Thalme L. Nave´r G. Bratt A. Karlsson A. Blaxhult M. Gissle´n B. Svennerholm I. Bergbrant Per Björkman C. Sa¨ll A˚ Mellgren A. Lindholm N. Kuylenstierna R. Montelius F. Azimi B. Johansson M. Carlsson E. Johansson B. Ljungberg H. Ekvall A. Strand S. Ma¨kitalo S. O¨berg P. Holmblad M. Ho¨fer H. Holmberg P. Josefson U. Ryding

subject

Male virus strain Resistance HIV Infections Drug resistance THERAPY Nucleoside Reverse Transcriptase Inhibitor ANTIRETROVIRAL DRUG-RESISTANCE 0302 clinical medicine Medical microbiology Genotype Medicine and Health Sciences Prevalence HIV Infection 030212 general & internal medicine UNITED-KINGDOM Phylogeny 0303 health sciences Communicable disease Transmission (medicine)adult virus mutation UPDATED RECOMMENDATIONS virus transmission 3. Good health Europe Infectious Diseases female risk factor virus resistance Female NAIVE PATIENTS SOCIETY-USA PANEL Research Article Human Adult medicine.medical_specialty Genotype Anti-HIV Agents Virus Article 03 medical and health sciences SDG 3 - Good Health and Well-being male MOLECULAR EPIDEMIOLOGY Drug Resistance Viral medicine proteinase inhibitor Humans Transmission controlled study human molecular phylogeny 030304 developmental biology nonhuman MUTATIONS business.industry Anti-HIV Agent nucleotide sequence nonnucleoside reverse transcriptase inhibitor Human immunodeficiency virus 1 infection Virology major clinical study unindexed sequence Parasitology 3121 General medicine internal medicine and other clinical medicine Mutation HIV-1 business

description

Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program.Methods: Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy.Results: The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained constant at 5%, a significant decline in protease inhibitors resistance mutations was observed, from 3.9% in 2002 to 1.6% in 2007 (p = 0.001). In contrast, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) doubled from 2.0% in 2002 to 4.1% in 2007 (p = 0.004) with 58% of viral strains carrying a K103N mutation. Phylogenetic analysis showed that these temporal changes could not be explained by large clusters of TDRM.Conclusion: During the years 2002 to 2007 transmitted resistance to NNRTI has doubled to 4% in Europe. The frequent use of NNRTI in first-line regimens and the clinical impact of NNRTI mutations warrants continued monitoring. © 2014 Frentz et al. licensee BioMed Central Ltd. 14 Cited By :16

year	journal	country	edition	language
2014-07-21

10.1186/1471-2334-14-407 http://gnosis.library.ucy.ac.cy/handle/7/53074