6533b7d4fe1ef96bd1262649
RESEARCH PRODUCT
Novel strategy for the synthesis of fluorinated β-amino acid derivatives from Δ2-oxazolines
Belén PinaCarmen Ramírez De ArellanoSantos FusteroEsther SalavertAmparo Asensiosubject
chemistry.chemical_classificationchemistryOrganic ChemistryDrug DiscoveryChemoselectivityBiochemistryCombinatorial chemistryAmino aciddescription
Abstract Racemic and chiral non-racemic β-fluoroalkyl-β-amino acid derivatives have been prepared in two steps starting from 2-alkyl-Δ2-oxazolines and fluorinated imidoyl chlorides. Subsequent chemoselective reduction of the C-masked β-enamino acid derivatives initially formed provided the target β-amino acids. The process takes place with total chemoselectivity, high yields and satisfactory diastereoselectivity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-07-01 | Tetrahedron |