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RESEARCH PRODUCT
Modelling cardiac mechanics of left ventricular noncompaction
Cesare ScardullaSalvatore PastaLeonardo D'acquistoAntonino RinaudoFrancesco Scardullasubject
medicine.medical_specialtygenetic structuresBiomedical EngineeringComputational MechanicsCardiomyopathy02 engineering and technology030218 nuclear medicine & medical imaging03 medical and health sciencesWall stress0302 clinical medicinecardiac mechanics finite element analysis Left ventricular noncompaction wall stressInternal medicine0202 electrical engineering electronic engineering information engineeringmedicineRadiology Nuclear Medicine and imagingbusiness.industryfungifood and beveragesmedicine.diseaseComputer Science ApplicationsCardiologyLeft ventricular noncompaction020201 artificial intelligence & image processingsense organsbusinessCardiac mechanicsdescription
Left ventricular noncompaction (LVNC) can be defined as a cardiomyopathy characterised by a pattern of prominent trabecular structure and deep intertrabecular recesses, that is thought to be caused by an arrest of normal endomyocardial morphogenesis. Using patient-specific computational modelling, we assessed the cardiac mechanics of five patients with LVNC and compared myocardial stress and pump performance to those of healthy controls. Findings shown that patients with LVNC have impaired left ventricular (LV) function, making it possible that the lack of fibre shortening of noncompacted layer can determine poor heart function. Pronounced end-systolic wall stress on left ventricular wall of patients with LVNC was observed when compared to that of normal hearts, and this may lead to adverse cardiac remodelling and ultimately heart failure. We hereby suggest that computational modelling can be considered as a useful tool to assess the cardiac work and pump performance of LVNC, which are responsible for progressive left ventricular deterioration and poor clinical course.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-10-04 |