6533b7d4fe1ef96bd1262840

RESEARCH PRODUCT

Association of interleukin-10G microsatellite polymorphism with the susceptibility of ankylosing spondylitis

Nada ČIkešWiebke Kaluza-schillingElisabeth Märker-hermannKsenija Mastrovic Radoncic

subject

musculoskeletal diseasesAdultMalechemical and pharmacologic phenomenaRheumatologyimmune system diseasesparasitic diseasesmedicineHumansGenetic Predisposition to DiseaseSpondylitis AnkylosingAnkylosing spondylitisPolymorphism Geneticbusiness.industryIL10 microsatellite polymorphisms ankylosing spondylitisInterleukinhemic and immune systemsJoint boneMiddle Agedmedicine.diseaseInterleukin-10Interleukin 10ImmunologyMicrosatelliteFemalebusinessAnkylosing spondylitis; Interleukin-10; Microsatellite polymorphismsMicrosatellite Repeats

description

Study suggests an association of IL10.G poly- morphisms with AS which might contribute to the increased or decreased susceptibility to AS. IL10.G8 and G7 microsatellites alleles appear as protective alleles against the development of AS in the German subjects investigated here. Allele IL10.G9 seems to be a risk factor for the development of AS. This protective effect of variant promoter alleles could be related to differences in IL- 10 production, which may be clinically relevant.

yearjournalcountryeditionlanguage
2013-01-01Joint Bone Spine
https://doi.org/10.1016/j.jbspin.2012.06.013