6533b7d4fe1ef96bd1262918

RESEARCH PRODUCT

Infections of susceptible and resistant mouse strains with herpes simplex virus type 1 and 2.

S. DundarovB. SchindlingL. CasparyDietrich Falke

subject

medicine.medical_specialtyanimal structuresvirusesSpleenHSL and HSVThymus GlandBiologymedicine.disease_causeVirusMiceMedical microbiologyImmunityVirologymedicineAnimalsSimplexvirusCyclophosphamidefungiBrainHerpes SimplexGeneral MedicineSpinal cordVirologyImmunity InnateMice Inbred C57BLHerpes simplex virusmedicine.anatomical_structureLiverSpinal CordInfectious disease (medical specialty)Spleen

description

The spread of HSV of type 1 and 2 was investigated after intraperitoneal, intraplantar and intracerebral infections of resistant (C57/bl) and susceptible (NMRI) mice. The virus spreads after i.p. infection to the spleen and the liver to the same extent in both strains of mice. However, virus is eliminated earlier in resistant mice. Intracerebral infections revealed a peculiar type of resistance of C57/bl mice especially for type 2 of HSV. HSV multiplies in the thymus at the early stage of infection and can be detected in this organ in sick mice of NMRI strain. HSV-1 and 2 can be detected in the spinal cord of C57/bl mice without sickness or death of these animals.

yearjournalcountryeditionlanguage
1980-09-01Archives of virology
10.1007/bf01314538https://pubmed.ncbi.nlm.nih.gov/6251783