0000000000235712

AUTHOR

L. Caspary

showing 2 related works from this author

Infections of susceptible and resistant mouse strains with herpes simplex virus type 1 and 2.

1980

The spread of HSV of type 1 and 2 was investigated after intraperitoneal, intraplantar and intracerebral infections of resistant (C57/bl) and susceptible (NMRI) mice. The virus spreads after i.p. infection to the spleen and the liver to the same extent in both strains of mice. However, virus is eliminated earlier in resistant mice. Intracerebral infections revealed a peculiar type of resistance of C57/bl mice especially for type 2 of HSV. HSV multiplies in the thymus at the early stage of infection and can be detected in this organ in sick mice of NMRI strain. HSV-1 and 2 can be detected in the spinal cord of C57/bl mice without sickness or death of these animals.

medicine.medical_specialtyanimal structuresvirusesSpleenHSL and HSVThymus GlandBiologymedicine.disease_causeVirusMiceMedical microbiologyImmunityVirologymedicineAnimalsSimplexvirusCyclophosphamidefungiBrainHerpes SimplexGeneral MedicineSpinal cordVirologyImmunity InnateMice Inbred C57BLHerpes simplex virusmedicine.anatomical_structureLiverSpinal CordInfectious disease (medical specialty)SpleenArchives of virology
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The effect of Dextransulfate 500 on the pathogenesis of herpes simplex virus infections in weanling mice

1978

Intraperitoneal (i.p.) injection of Dextran Sulfate (D.S.) 500 during a limited period of time influences the course of herpes simplex-virus-infections. D.S.500 was found to reduce the resistance of mice for some herpes simplex-virus strains (Len, L3-2s, Haase) if given between 16 hours before and 2 hours after i.p. infection. The decrease of resistance could be correlated with an increase of the virus content of liver, spleen, brain and spinal cord. Injection of herpes simplex-virus-specific immune serum counteracted the effect of D.S.500 on the course of infections. Conversely, D.S.500 increased the resistance of mice to another group of herpes simplex-viruses (strains D-316, Thea, DD), i…

medicine.medical_specialtyTime FactorsvirusesWeanlingMice Inbred StrainsSpleenBiologymedicine.disease_causeVirusPathogenesisMicePeritoneal cavityMedical microbiologySpecies SpecificityVirologymedicineAnimalsSimplexvirusMacrophagesDextransHerpes SimplexGeneral MedicineSpinal cordVirologyHerpes simplex virusmedicine.anatomical_structureImmunologyAdsorptionArchives of Virology
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