6533b7d4fe1ef96bd12629a5

RESEARCH PRODUCT

Multifunctional Carrier Based on Halloysite/Laponite Hybrid Hydrogel for Kartogenin Delivery

Luca AristaG. SpinelliFrancesco Di BlasiMarina MassaroFrancesca D'annaCarla RizzoGiuseppe CavallaroGiuseppa BiddeciSerena RielaThomas UllrichGabriella BuscemiAngelo FerranteGiuseppe Lazzara

subject

Materials scienceCarrier system010405 organic chemistryOrganic ChemistryComposite numbertechnology industry and agricultureSettore CHIM/06 - Chimica Organicamacromolecular substancesengineering.materialcomplex mixtures01 natural sciencesBiochemistryHalloysite0104 chemical sciencesKartogenin010404 medicinal & biomolecular chemistryHalloysite nanotubes kartogenin hybrid laponite hydrogelChemical engineeringDrug DiscoveryengineeringSettore CHIM/02 - Chimica Fisica

description

[Image: see text] A novel carrier system based on halloysite nanotubes (HNT), for the potential intraarticular delivery of kartogenin (KGN) by means laponite (Lap) hydrogel (HNT/KGN/Lap), is developed. The drug was first loaded into HNT, and the hybrid composite obtained was used as filler for laponite hydrogel. Both the filler and the hydrogel were thoroughly investigated by several techniques and the hydrogel morphology was imaged by transmission electron microscopy. Furthermore, the gelating ability of laponite in the presence of the filler and the rheological properties of the hybrid hydrogel were also investigated. The kinetic release of kartogenin from HNT and HNT/Lap hybrid hydrogel was studied both in physiological conditions and in ex vivo synovial fluid. In the last case, the kinetic results highlighted that HNT carrier can effectively release KGN in a sustained manner for at least 38 days. Finally, a preliminary biological assays showed that the HNT/KGN/Lap hybrid hydrogel did not exhibit any cytotoxic effect.

yearjournalcountryeditionlanguage
2018-10-22ACS Medicinal Chemistry Letters
https://doi.org/10.1021/acsmedchemlett.8b00465