6533b7d4fe1ef96bd12631de

RESEARCH PRODUCT

Novel strategies in the war against antibiotic resistance

Patrizia DianaBarbara ParrinoDaniela CarboneCamilla PecoraroStella Cascioferro

subject

Methicillin-Resistant Staphylococcus aureusPharmacologyVirulencebiologyChemistryEscherichia coli ProteinsProtein Disulfide-IsomerasesBiofilmDrug Resistance MicrobialAnti-Bacterial AgentsMicrobiologyDsbAAntibiotic resistanceBiofilmsDrug DiscoveryEscherichia colibiology.proteinMolecular Medicineantibiotic resistance antivirulence strategy biofilm DsbA MRSA

description

The global threat of antibiotic resistance is steadily growing. Antibiotic resistancemay involve any class of antibiotic, including second- and third-line agents that have been considered to date the last-resort drugs to counteract common infections. We may lose our capability to keep under control many common bacterial infections [1]. Despite this, in the past decade significant research efforts have been made to develop new antibacterial strategies able to treat multidrug-resistant infections; however, no new therapeutic approach has yet reached the clinic [2,3]. In order to identify new valuable antimicrobial drugs, it is important to consider the main bacterial resistance mechanisms in both planktonic and sessile forms of life [4].

yearjournalcountryeditionlanguage
2021-03-01
10.4155/fmc-2021-0009http://hdl.handle.net/10447/533166