6533b7d4fe1ef96bd126329b
RESEARCH PRODUCT
Stereoselective aldol reaction catalyzed by a highly recyclable polystyrene supported substituted prolinamide catalyst
Michelangelo GruttadauriaRenato NotoFrancesco GiacaloneAdriana Mossuto MarculescuAnna Maria Pia Salvosubject
organocatalysis proline aldol reaction polystyrenechemistry.chemical_compoundChloroformchemistryAldol reactionFormic acidOrganocatalysisOrganic ChemistryAcetoneCyclohexanoneOrganic chemistryPolystyreneCatalysisdescription
Polystyrene supported substituted prolinamide was used as catalyst in the aldol reaction between cyclohexanone or acetone and several substituted benzaldehydes in chloroform/water. This catalyst afforded aldol products in high yields and stereoselectivities, especially in the case of reactions performed with acetone. The catalyst was easily recovered by filtration and reused, after regeneration with formic acid, up to 22 times.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-09-26 |