6533b7d4fe1ef96bd12633e7
RESEARCH PRODUCT
Inhibition of ethoxyresorufin deethylase activity by natural flavonoids in human and rat liver microsomes
Marie-hélène SiessPatrick RatAnne-marie Le BonM. Suschetetsubject
MaleHealth Toxicology and Mutagenesis[SDV]Life Sciences [q-bio]MorinToxicology030226 pharmacology & pharmacyFlavonesStructure-Activity Relationship03 medical and health scienceschemistry.chemical_compound0302 clinical medicineFlavonolsSpecies SpecificityCytochrome P-450 CYP1A1AnimalsCytochrome P-450 Enzyme InhibitorsHumansStructure–activity relationshipheterocyclic compoundsChrysinComputingMilieux_MISCELLANEOUS030304 developmental biologyFlavonoidschemistry.chemical_classification0303 health sciencesPublic Health Environmental and Occupational HealthRats Inbred StrainsGeneral ChemistryRats3. Good healthchemistryBiochemistryChemistry (miscellaneous)Microsomes LiverMicrosomeRATOxidoreductasesQuercetinLuteolinFood Sciencedescription
Several flavones and flavonols (chrysin, quercetin, luteolin, flavone and 7, 8-benzoflavone) were found to inhibit ethoxyresorufin deethylase (EROD) activity in human and rat liver microsomes. In man, molecules without hydroxyl groups are more powerful inhibitors than polyhydroxylated flavonoids (7, 8-benzoflavone greater than flavone greater than chrysin greater than luteolin greater than quercetin greater than morin). In rat, chrysin was the strongest inhibitor and the less effective were morin and 7,8-benzoflavone. For all molecules human microsomes were more sensitive than rat microsomes. The most important difference concerned 7,8-benzoflavone which was 10,000-fold more potent in man.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-01-01 |