6533b7d4fe1ef96bd12634ac

RESEARCH PRODUCT

Correction: Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study

Isabelle Thierry ChefMarc MaynadiéElisa PasqualYolanda BenaventeLenka ForetovaPaul BrennanEsther Gracia-lavedanDelphine CasabonneMichelle C. TurnerPierluigi CoccoAnthony StainesSilvia De SanjoséAlexandra NietersPaolo BoffettaElisabeth Cardis

subject

MaleLimfomesLymphoma[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/ImagingPhysiologyLogistic regressionPediatrics030218 nuclear medicine & medical imagingDiagnostic RadiologyHematologic Cancers and Related Disorders0302 clinical medicineRisk FactorsBone MarrowRadiation IonizingImmune PhysiologyOdds RatioMedicine and Health SciencesMedicineFamily historyCàncerCancerCancer risk factorseducation.field_of_studyMultidisciplinaryFactors de risc en les malaltiesRadiology and ImagingQConfoundingRHematologyMiddle AgedRadiation ExposureBone Imaging3. Good healthOncology030220 oncology & carcinogenesisMedicineFemaleLymphomasResearch ArticleAdultmedicine.medical_specialtyRisk factors in diseasesImaging TechniquesSciencePopulationImmunology[SDV.CAN]Life Sciences [q-bio]/CancerRadiation DosageResearch and Analysis Methods03 medical and health sciences[SDV.CAN] Life Sciences [q-bio]/CancerRheumatologyDiagnostic MedicineInternal medicineOsteoarthritisCancer Detection and DiagnosisHumansMedical historyeducationAgedbusiness.industryArthritisCase-control studyCorrectionCancers and NeoplasmsBiology and Life SciencesOdds ratiomedicine.diseaseLymphomaX-Ray RadiographyMedical risk factorsLogistic Models[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieCase-Control StudiesImmune System[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologiebusiness

description

International audience; Medical diagnostic X-rays are an important source of ionizing radiation (IR) exposure in the general population; however, it is unclear if the resulting low patient doses increase lymphoma risk. We examined the association between lifetime medical diagnostic X-ray dose and lymphoma risk, taking into account potential confounding factors, including medical history. The international Epilymph study (conducted in the Czech-Republic, France, Germany, Ireland, Italy, and Spain) collected self-reported information on common diagnostic X-ray procedures from 2,362 lymphoma cases and 2,465 frequency-matched (age, sex, country) controls. Individual lifetime cumulative bone marrow (BM) dose was estimated using time period-based dose estimates for different procedures and body parts. The association between categories of BM dose and lymphoma risk was examined using unconditional logistic regression models adjusting for matching factors, socioeconomic variables, and the presence of underlying medical conditions (atopic, autoimmune, infectious diseases, osteoarthritis, having had a sick childhood, and family history of lymphoma) as potential confounders of the association. Cumulative BM dose was low (median 2.25 mGy) and was not positively associated with lymphoma risk. Odds ratios (ORs) were consistently less than 1.0 in all dose categories compared to the reference category (less than 1 mGy). Results were similar after adjustment for potential confounding factors, when using different exposure scenarios, and in analyses by lymphoma subtype and by type of control (hospital-, population-based). Overall no increased risk of lymphoma was observed. The reduced ORs may be related to unmeasured confounding or other sources of systematic bias.We found little evidence that chronic medical conditions confound lymphoma risk and medical radiation associations.

10.1371/journal.pone.0235658http://europepmc.org/articles/PMC7351167