6533b7d5fe1ef96bd1263c52

RESEARCH PRODUCT

Comparative study of the lubricant performance of Compritol® HD5 ATO and Compritol® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity

V BérardY. PourcelotC. AndrèsA. N’diayeVincent Jannin

subject

GlycerolMaterials scienceCompressive StrengthChemistry PharmaceuticalPharmaceutical ScienceExcipientLactosePolyethylene glycolCompritol HD5 ATODosage formCompritol 888Polyethylene Glycolschemistry.chemical_compoundPharmaceutical technologyTensile StrengthLubricationmedicineOrganic chemistryParticle SizeLubricantGLYCERYL DIBEHENATEFatty AcidschemistryChemical engineeringMicroscopy Electron ScanningTabletsmedicine.drug

description

The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization. This material is compared to Compritol 888 ATO, constituted only by glyceryl dibehenate. First, this study verifies that Compritol HD5 ATO and Compritol 888 ATO present the same granular characteristics and that their mixes with Lactopress present no structural differences. Secondly, in term of compressibility and cohesiveness, the use of Compritol 888 ATO or Compritol HD5 ATO with Lactopress does not involve any significant modification. Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has no consequence in compression practice. The presence of polyethylene glycol behenate does not decrease the glyceryl dibehenate compression functionality. This study concludes that Compritol HD5 ATO could be a very interesting excipient because it associates the glyceryl dibehenate lubricant capacity with the polyethylene glycol behenate-specific capacity in terms of dissolution enhancement.

yearjournalcountryeditionlanguage
2003-03-01International Journal of Pharmaceutics
https://doi.org/10.1016/s0378-5173(03)00027-9